The Effect of the Central Administration of the Neuropeptide VF on Feed Intake and Its Possible Interactions with Glutamate and Opioid Systems in Broiler Chicken

Arginine-phenylalanine-amide (RFamide)-related peptides known as neuropeptide VF (NPVF) have a crucial role in feeding regulation. The present study purposed to determine the effect of intracerebroventricular (ICV) injection NPVF on dietary intake and possible interactions with glutamate opioid systems broiler chicken. In experiment 1, chickens received ICV administration control solution, (16 nmol), 15 nmol MK-801 (NMDA receptors antagonist), together. experiments, 2–8 were injected intracerebroventricularly 390 CNQX (antagonist AMPA receptors), 2 AIDA (an antagonist mGLUR1 150 LY341495 mGLUR2 UBP1112 for mGLUR3 5 µg β-FNA mu (µ) NTI delta (δ) nor-BNI (kappa (κ) antagonist; µg) instead MK-801. Following injection, at 30, 60, 120 min, chick's was recorded. As result, nmol) reduced feed broilers (P < 0.05). + co-injection hypophagic action Injection together anorectic Co-injection effects Thus, newborn broilers, NPVF-induced anorexia is probably mediated by NMDA/ µ receptors.